BlueWillow’s intranasal vaccine platform has successfully demonstrated safety and immunogenicity in humans with a seasonal flu vaccine, and safety and efficacy in primary animal models for several other diseases. In 2020, BlueWillow will initiate Phase 1 human studies for two intranasal vaccine programs — pandemic flu and anthrax — both of which will be funded by NIH.
The company has also demonstrated that it’s nanotechnology platform can be used to develop intranasal immunotherapy (INIT) for food and respiratory allergies. In 2019, BlueWillow received an SBIR Fast-Track contract to develop intranasal immunotherapy for peanut allergy. To date, BlueWillow’s INIT product has been shown to (i) induce mucosal immune responses in the gastrointestinal tract, (ii) elicit a Th2 to Th1 shift, (iii) suppress IgE antibody production and (iv) prevent inflammatory allergic responses upon subsequent exposure to peanut allergen.
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