There are many obvious advantages of delivering vaccines via a simple nasal spray vs. an injection through the skin:
- Needle-free vaccine delivery overcomes a significant portion of vaccine reluctance amongst the public enabling increased vaccine adoption critical during pandemic or endemic outbreaks.
- Ease of administration leads to wider vaccine availability as specialized training for delivery is not required. Self-administration of vaccines becomes feasible.
- Supply chain costs are reduced addressing barriers to vaccine in low- and middle- income countries and regions.
- Multi-dose vials are achievable further facilitating widespread vaccine delivery.
- Intranasal vaccination leads to a mucosal, cell-mediated and systemic immune response that more directly mimics immunity gained from natural infection.
How Do Intranasal NanoVax® Vaccines Work?
NanoVax® adjuvanted vaccines are applied intranasally via a simple spray device. As shown in the figure below, the adjuvant efficiently delivers antigens to local dendritic cells. The dendritic cells take-up and deliver the antigen(s) to regional lymph nodes initiating the immune response. This path of vaccination results in potent mucosal, systemic and cell-mediated immunity.
